Antidote for lovenox2/14/2023 ![]() ![]() ![]() Portola Pharmaceuticals is developing PRT064445, a specific FXa inhibitor antidote that reverses the anticoagulant activity of the three currently available oral direct FXa inhibitors (rivaroxaban, apixaban, and betrixaban) and that of enoxaparin and fondaparinux. Lauw from McMaster University in Hamilton, Ontario, Canada, and colleagues reviewed three specific antidotes that are being developed. The use of DOACs can be associated with serious bleeding, and the lack of specific antidotes has raised concerns about the inability to reverse their effects in patients with major bleeding and in those who require emergency surgery, researchers write in the Canadian Journal of Cardiology, online January 25.ĭr. NEW YORK (Reuters Health) - Several antidotes to specific direct oral anticoagulants (DOAC) are in the pipeline, according to a recent review. ![]()
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